PhD Position in Identifying Small Molecule Inhibitors of Alzheimer’s Disease Through a Combination of Microfluidics and Fluorescence Imaging

100%, Zurich, fixed-term

The deMello Group in the Department of Chemistry and Applied Biosciences at ETH Zürich, a world-leading center for the development of novel microfluidic technologies, is looking for a motivated PhD candidate to develop state-of-the-art microfluidic and imaging techniques for identifying inhibitors of Alzheimer’s disease.

Project background

Alzheimer’s disease (AD) remains a global challenge, lacking effective treatments. Current drugs offer limited benefits, highlighting an urgent need for novel therapeutic strategies. A primary factor limiting the identification of new drug candidates is the dearth of robust, time- and cost-effective screening methods. High-throughput screening methods are critical for drug discovery but are commonly unable to mimic the brain microenvironment or provide detailed mechanistic insights. Microfluidics offers a powerful experimental platform able to recreate physiologically relevant conditions and perform rapid and cost-effective screening of chemical libraries.

Job description

The aim of this project is to develop microfluidic platforms able to identify small molecule inhibitors that target AD. Specifically, a combination of microfluidics, time-resolved and super -resolution fluorescence imaging, and high-throughput screening will be used to accelerate the discovery of novel therapeutics under conditions that mimic the physiological environment of cell membranes.

Key Responsibilities:

• Design, fabricate and operate microfluidic devices
• Develop assays to monitor aggregation kinetics in real time
• Screen chemical libraries to identify potential therapeutic candidates
• Collaborate closely with protein engineers to prepare diverse drug candidate libraries
• Prepare high-quality publications and present findings at international conferences

Profile

The successful candidate should hold:

• An MSc degree in chemistry, biology, engineering, or a related discipline with excellent grades
• Experience in fluorescence imaging, microfabrication, microfluidics, biophysical characterization of biomolecules, protein biochemistry will be beneficial
• Fluent communication skills (written and presentation) in English are essential

Workplace

We offer

ETH Zurich is a family-friendly employer with excellent working conditions. You can look forward to an exciting working environment, cultural diversity and attractive offers and benefits.

Working, teaching and research at ETH Zurich

We value diversity

In line with our values , ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish.

Curious? So are we.

We look forward to receiving online applications that include:

• CV
• copies of all Bachelor and Master certificates
• transcripts and letter of motivation

Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.

Specific questions regarding the position can be directed to Dr Stavros Stavrakis, by email (stavros.stavrakis@ chem.ethz.ch)

Apply online now

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.